On April 7, 2025, New Mexico became the third state in the U.S. to legalize psilocybin-assisted therapy, following Oregon and Colorado. Governor Michelle Lujan Grisham signed Senate Bill 219, known as the Medical Psilocybin Act, into law, establishing a regulated framework for the medical use of psilocybin. Cannacore Group+1Psycle Health+1
Unlike Oregon and Colorado, which passed their psilocybin measures through voter initiatives—Measure 109 in Oregon (2020) and Proposition 122 in Colorado (2022) —New Mexico’s legislation was enacted directly by the state legislature, reflecting broad bipartisan support. Wikipedia+1Mugglehead Investment Magazine+1Psychedelic Alpha
The Medical Psilocybin Act allows for the therapeutic use of psilocybin to treat conditions such as major treatment-resistant depression, post-traumatic stress disorder, substance use disorders, and end-of-life care. The Act also establishes a nine-member Medical Psilocybin Advisory Board to oversee the program’s implementation. New Mexico Legislature
This legislative milestone positions New Mexico at the forefront of integrative mental health therapies, offering new hope for individuals seeking alternative treatments.
🌱 1. Evidence-Based Mental Health Support
Clinical studies from top institutions like Johns Hopkins, NYU, and Imperial College London have shown psilocybin’s potential to:
- Reduce symptoms of treatment-resistant depression
- Alleviate PTSD and anxiety (especially in end-of-life care)
- Help with substance use disorders (alcohol, nicotine, opioids)
Plant medicines aren’t replacing traditional therapy—they’re enhancing it.
🧠 2. Addresses the Mental Health Crisis
We’re in a mental health emergency. Rates of anxiety, depression, and suicide continue to rise across the country. Current medications don’t work for everyone. Offering more options—especially ones that promote long-term healing after just a few sessions—could be life-changing for millions.
🌎 3. Culturally Rooted, Historically Revered
Plant medicines have been used by Indigenous cultures for thousands of years for healing, connection, and personal growth. Integrating them respectfully into modern therapy is a way to honor that wisdom—not ignore it.
❤️ 4. Holistic, Heart-Centered Healing
Plant medicine therapy encourages inner reflection, emotional release, spiritual connection, and a sense of unity—qualities often missing from conventional treatment models. This approach aligns beautifully with integrative health, which considers the whole person: mind, body, and spirit.
🧑⚖️ 5. Safe When Regulated
Legalization paired with clear regulation ensures:
- Safe, clinical environments
- Proper training for facilitators
- Ethical, supportive integration practices
This reduces the risk of misuse and maximizes therapeutic benefit.
Find out more about your state.


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